doi: 10.1039/c1cc14824a.
Epub 2011 Sep 16.
Proteome profiling reveals potential cellular targets of staurosporine using a clickable cell-permeable probe
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- PMID: 21922114
- DOI: 10.1039/c1cc14824a
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Proteome profiling reveals potential cellular targets of staurosporine using a clickable cell-permeable probe
Chem Commun (Camb).
.
Abstract
A clickable, affinity-based probe (AfBP), which was modified from staurosporine (a natural product kinase inhibitor), has been synthesized and used in situ for activity-based proteome profiling of potential cellular targets of staurosporine in HepG2 cancer cells.
This journal is © The Royal Society of Chemistry 2011
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