The galvanizing of Mycobacterium tuberculosis: an antimicrobial mechanism
- PMID: 21925106
- PMCID: PMC3177235
- DOI: 10.1016/j.chom.2011.08.008
The galvanizing of Mycobacterium tuberculosis: an antimicrobial mechanism
Abstract
Evolving under constant threat from invading microbes, macrophages have acquired multiple means of killing bacteria. In this issue of Cell Host & Microbe, Botella and colleagues (Botella et al., 2011) describe a novel antimicrobial mechanism based on elevated levels of intraphagosomal Zn(2+) and the corresponding induction of bacterial genes to ameliorate this host-derived stress.
Copyright © 2011 Elsevier Inc. All rights reserved.
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Comment on
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Mycobacterial p(1)-type ATPases mediate resistance to zinc poisoning in human macrophages.Cell Host Microbe. 2011 Sep 15;10(3):248-59. doi: 10.1016/j.chom.2011.08.006. Cell Host Microbe. 2011. PMID: 21925112 Free PMC article.
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- Botella H, Peyron P, Levillian F, Poincloux R, Poquet Y, Brandli I, Wang C, Tailleux L, Tilleul S, Charriere G, Waddell S, Foti M, Lugo-Villarino G, Gao Q, Marridonneau-Parini I, Butcher PD, Castagnoli PR, Gicquel B, de Chastellier C, Neyrolles O. P1-type ATPases mediate microbial resistance to zinc poisoning in human macrophages. Cell, Host and Microbe. 2011 (In this issue) - PMC - PubMed
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