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Multicenter Study
. 2012 Jan;71(1):84-7.
doi: 10.1136/annrheumdis-2011-200086. Epub 2011 Sep 16.

Efficacy of rituximab in primary Sjogren's syndrome with peripheral nervous system involvement: results from the AIR registry

A Mekinian  1 , P Ravaud, P Y Hatron, C Larroche, J Leone, B Gombert, M Hamidou, A Cantagrel, C Marcelli, S Rist, M Breban, D Launay, O Fain, J E Gottenberg, X Mariette
Affiliations
Multicenter Study

Efficacy of rituximab in primary Sjogren's syndrome with peripheral nervous system involvement: results from the AIR registry

A Mekinian et al. Ann Rheum Dis. 2012 Jan.

Abstract

Objective: To evaluate rituximab (RTX) in primary Sjögren's syndrome (pSS) with peripheral nervous system (PNS) involvement.

Methods: Patients with pSS and PNS involvement who were included in the French AIR registry were analysed.

Results: 17 patients (age 60 years (44-78 years); 14 were female) were analysed. Neurological improvement was noted in 11 patients (65%) at 3 months. Rankin scale decreased from 3 (1-5) to 2 (1-5), 2 (1-5) and 2 (1-6) after 3, 6 and 9 months (p=0.02). European Sjögren's Syndrome Disease Activity Index decreased from 18 (10-44) to 11 (5-20), 11 (5-29) and 12 (5-30) after 3, 6 and 9 months (p<0.05). RTX was effective in neurological involvement in 9/10 patients with vasculitis or cryoglobulinaemia (90%) (group 1) at 3 months and in 2/7 cases (29%) without cryoglobulinaemia and vasculitis (p=0.03). Rankin and European Sjögren's Syndrome Disease Activity Index scales decreased significantly in group 1.

Conclusion: RTX seems effective in cryoglobulinaemia or vasculitis-related PNS involvement in pSS.

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