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. 2012 Apr;26(4):858-60.
doi: 10.1038/leu.2011.250. Epub 2011 Sep 16.

Frequency of leukemic initiating cells does not depend on the xenotransplantation model used

J Vargaftig, D C Taussig, E Griessinger, F Anjos-Afonso, T A Lister, J Cavenagh, H Oakervee, J Gribben, D Bonnet

Frequency of leukemic initiating cells does not depend on the xenotransplantation model used

J Vargaftig et al. Leukemia. 2012 Apr.
No abstract available

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Figures

Figure 1
Figure 1
Frequency of LICs obtained in NOD/SCID and NSG. Five different doses of AML cells were injected in a group of 5 mice per dose. After 12 weeks, the level of engraftment was evaluated by FACS. For each engraftment of human CD45+CD33+CD19− higher than 0.1% the mouse was consider positive. Frequency of LICs was calculated using the extreme limiting dilution analysis (ELDA) software.
Figure 2
Figure 2
Overall survival curve of non-engrafters and low and high LICs frequency groups in months. The difference between non-engrafters and low frequency LICs p: < 0.034. No significant difference between low and high frequency of LICs (median 8.5 and 7 months respectively).
See this image and copyright information in PMC

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