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. 2011 Sep 18;17(10):1315-9.
doi: 10.1038/nm.2472.

Intraoperative tumor-specific fluorescence imaging in ovarian cancer by folate receptor-α targeting: first in-human results

Gooitzen M van Dam  1 , George Themelis, Lucia M A Crane, Niels J Harlaar, Rick G Pleijhuis, Wendy Kelder, Athanasios Sarantopoulos, Johannes S de Jong, Henriette J G Arts, Ate G J van der Zee, Joost Bart, Philip S Low, Vasilis Ntziachristos
Affiliations

Intraoperative tumor-specific fluorescence imaging in ovarian cancer by folate receptor-α targeting: first in-human results

Gooitzen M van Dam et al. Nat Med. .

Abstract

The prognosis in advanced-stage ovarian cancer remains poor. Tumor-specific intraoperative fluorescence imaging may improve staging and debulking efforts in cytoreductive surgery and thereby improve prognosis. The overexpression of folate receptor-α (FR-α) in 90-95% of epithelial ovarian cancers prompted the investigation of intraoperative tumor-specific fluorescence imaging in ovarian cancer surgery using an FR-α-targeted fluorescent agent. In patients with ovarian cancer, intraoperative tumor-specific fluorescence imaging with an FR-α-targeted fluorescent agent showcased the potential applications in patients with ovarian cancer for improved intraoperative staging and more radical cytoreductive surgery.

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Comment in

  • Imaging: Lighten up tumors.
    Villanueva MT. Villanueva MT. Nat Rev Clin Oncol. 2011 Sep 27;8(11):628. doi: 10.1038/nrclinonc.2011.146. Nat Rev Clin Oncol. 2011. PMID: 21946844 No abstract available.

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