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Randomized Controlled Trial
. 2011 Oct;13(10):706-11.
doi: 10.1111/j.1477-2574.2011.00357.x. Epub 2011 Jul 22.

Ketamine does not inhibit interleukin-6 synthesis in hepatic resections requiring a temporary porto-arterial occlusion (Pringle manoeuvre): a controlled, prospective, randomized, double-blinded study

Francisco Carlos Bonofiglio  1 , Ernesto P Molmenti, Eduardo de Santibañes
Affiliations
Randomized Controlled Trial

Ketamine does not inhibit interleukin-6 synthesis in hepatic resections requiring a temporary porto-arterial occlusion (Pringle manoeuvre): a controlled, prospective, randomized, double-blinded study

Francisco Carlos Bonofiglio et al. HPB (Oxford). 2011 Oct.

Abstract

Introduction: Previous studies have shown that interleukin-6 (IL-6) levels correlated with mortality in critically ill patients.

Goal: To determine the effect of ketamine on IL-6 levels in liver resections patients with a temporary porto-arterial occlusion (Pringle manoeuvre).

Materials and methods: Controlled, prospective, randomized, double-blinded study. One group (n = 21) received ketamine whereas the other group (n = 17) received placebo. IL-6 levels were obtained at baseline, 4, 12, 24 h, 3 and 5 days.

Results: There were no significant differences in IL-6 levels between the groups (basal P = 089, 4 hP = 0.83, 12 h P = 0.39, 24 h, P = 0.55, 3 days P = 0.80 and 5 days P = 0.45). Both groups had elevated IL-6 levels that became almost undetectable by day 5. There was no major morbidity and no mortality in either group.

Conclusions: Ketamine does not seem to have an effect on plasma levels of IL-6. This could be interpreted as a potential finding associated with outcome as we did not encounter any deaths or major complications. Further studies will likely be needed to determine the range of IL-6 levels associated with survival and mortality, and whether it could be a predictor of survival.

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Figures

Figure 1
Figure 1
CONSORT diagram detailing the study. Placebo group: males n = 12, memales n = 8. Ketamine group: males n = 12, females n = 10. (a) one patient with a haematocrit <20% for >30 min during surgery. Two patients did not require the Pringle manoeuver. (b) One patient did not undergo the planned surgical procedure
Figure 2
Figure 2
Line graph comparing plasma levels of interleukin-6 (IL 6) (in pg/ml) for both groups of the study
See this image and copyright information in PMC

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