Comment on

• Activation of platelets by heparin-induced thrombocytopenia antibodies in the serotonin release assay is not dependent on the presence of heparin.

  Prechel MM, McDonald MK, Jeske WP, Messmore HL, Walenga JM. Prechel MM, et al. J Thromb Haemost. 2005 Oct;3(10):2168-75. doi: 10.1111/j.1538-7836.2005.01560.x. Epub 2005 Sep 9. J Thromb Haemost. 2005. PMID: 16150048
• Lepirudin in patients with heparin-induced thrombocytopenia - results of the third prospective study (HAT-3) and a combined analysis of HAT-1, HAT-2, and HAT-3.

  Lubenow N, Eichler P, Lietz T, Greinacher A; Hit Investigators Group. Lubenow N, et al. J Thromb Haemost. 2005 Nov;3(11):2428-36. doi: 10.1111/j.1538-7836.2005.01623.x. J Thromb Haemost. 2005. PMID: 16241940 Clinical Trial.
• Heparin-independent activation of platelets by heparin-induced thrombocytopenia antibodies: a common occurrence.

  Socher I, Kroll H, Jorks S, Santoso S, Sachs UJ. Socher I, et al. J Thromb Haemost. 2008 Jan;6(1):197-200. doi: 10.1111/j.1538-7836.2007.02815.x. Epub 2007 Oct 23. J Thromb Haemost. 2008. PMID: 17956599 No abstract available.
• Heparin-induced thrombocytopenia--therapeutic concentrations of danaparoid, unlike fondaparinux and direct thrombin inhibitors, inhibit formation of platelet factor 4-heparin complexes.

  Krauel K, Fürll B, Warkentin TE, Weitschies W, Kohlmann T, Sheppard JI, Greinacher A. Krauel K, et al. J Thromb Haemost. 2008 Dec;6(12):2160-7. doi: 10.1111/j.1538-7836.2008.03171.x. Epub 2008 Oct 3. J Thromb Haemost. 2008. PMID: 18983520
• Fondaparinux treatment of acute heparin-induced thrombocytopenia confirmed by the serotonin-release assay: a 30-month, 16-patient case series.

  Warkentin TE, Pai M, Sheppard JI, Schulman S, Spyropoulos AC, Eikelboom JW. Warkentin TE, et al. J Thromb Haemost. 2011 Dec;9(12):2389-96. doi: 10.1111/j.1538-7836.2011.04487.x. J Thromb Haemost. 2011. PMID: 21883878