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Comparative Study
. 2011 Sep;46(9):1759-63.
doi: 10.1016/j.jpedsurg.2011.03.070.

Effectiveness of Biobrane for treatment of partial-thickness burns in children

Aaron P Lesher  1 , Ryan H Curry, Jill Evans, Valerie A Smith, Michael T Fitzgerald, Robert A Cina, Christian J Streck, Andre V Hebra
Affiliations
Comparative Study

Effectiveness of Biobrane for treatment of partial-thickness burns in children

Aaron P Lesher et al. J Pediatr Surg. 2011 Sep.

Abstract

Purpose: Wound care for partial-thickness burns should alleviate pain, decrease hospital length of stay, and be readily applied to a variety of wounds. The effectiveness of Biobrane (UDL Laboratories, Rockford, IL) is compared with that of Beta Glucan Collagen (BGC; Brennan Medical, St. Paul, MN) in a retrospective cohort study.

Methods: A retrospective chart review of all children treated at a tertiary care pediatric hospital between 2003 and 2009 identified patients with partial-thickness burns treated with Biobrane. These patients were compared with historical controls treated with BGC.

Results: A total of 235 children between the ages of 4 weeks and 18 years with an average of 6.0% body surface area partial-thickness burns were treated with Biobrane. In a multivariate statistical analysis, patients treated with Biobrane healed significantly faster than those treated with BGC (Biobrane vs BGC: median, 9 vs 13 days; P = .019; hazard ratio, 1.68). In addition, patients who required inpatient treatment trended toward having shorter length of hospital stay in the Biobrane group (2.6 vs 4.1 days, P = .079).

Conclusion: Partial-thickness burn care consists of early debridement and application of a burn wound dressing. Biobrane dressings result in faster healing compared with BGC and may decrease hospital length of stay for patients requiring inpatient admission.

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Figures

Fig. 1
Fig. 1
Time-to-healing analysis of Biobrane vs BGC in pediatric partial-thickness burns. Using the Cox proportional hazards model, the days to complete healing of the burn is demonstrated for Biobrane (solid line) vs BGC (dotted line). The hazard ratio associated with healing time comparing Biobrane vs BGC was 1.68, meaning that a patient receiving the Biobrane treatment who has not yet healed by a certain day has 1.68 times the chance of being healed by the next day compared with someone in the BGC group (hazard ratio, 1.68*; 95% confidence interval, 1.09–2.60). *Cox proportional hazards test.
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References

    1. Brigham PA, McLoughlin E. Burn incidence and medical care use in the United States: estimates, trends, and data sources. J Burn Care Rehabil. 1996;17:95–107. - PubMed
    1. Bishop JF. Pediatric considerations in the use of Biobrane in burn wound management. J Burn Care Rehabil. 1995;16:311–314. - PubMed
    1. Delatte SJ, Evans J, Hebra AV, et al. Effectiveness of Beta-glucan collagen for treatment of partial-thickness burns in children. J Pediatr Surg. 2001;36:113–118. - PubMed
    1. Honari S. Topical therapies and antimicrobials in the management of burn wounds. Crit Care Nurs Clin North Am. 2004;16:1–11. - PubMed
    1. Lukish JR, Eichelberger MR, Newman KD, et al. The use of a bioactive skin substitute decreases length of stay for pediatric burn patients. J Pediatr Surg. 2001;36:1118–1121. - PubMed

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