Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2011 Oct;23(5):317-25.
doi: 10.1016/j.smim.2011.08.004. Epub 2011 Sep 18.

Factors and networks that underpin early hematopoiesis

Elinore M Mercer  1 , Yin C Lin, Cornelis Murre
Affiliations
Review

Factors and networks that underpin early hematopoiesis

Elinore M Mercer et al. Semin Immunol. 2011 Oct.

Abstract

Multiple trajectories have recently been described through which hematopoietic progenitor cells travel prior to becoming lineage-committed effectors. A wide spectrum of transcription factors has recently been identified that modulate developmental progression along such trajectories. Here we describe how distinct families of transcription factors act and are linked together to orchestrate early hematopoiesis.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Schematic diagram indicating developmental trajectories in early hematopoiesis. Transcription factors that act at distinct steps in hematopoiesis are indicated. HSC refers to hematopoietic stem cell. MPP indicates multipotent progenitor. LMPP refers to lymphoid-primed multipotent progenitor. GMP indicates the granulocyte-macrophage progenitor compartment. MEP indicates the premegakaryocytic/erythroid progenitor compartments. CLP refers to common lymphoid progenitor compartment. Gran refers to granulocytes. Mac indicates the macrophage compartment. ETP refers to early thymocyte progenitor.
See this image and copyright information in PMC

References

    1. Weissman IL. Stem Cells: Units of Development, Units of Regeneration, and Units in Evolution. Cell. 2000;100:157–168. - PubMed
    1. Spangrude G, Heimfeld S, Weissman I. Purification and characterization of mouse hematopoietic stem cells. Science. 1988;241:58–62. - PubMed
    1. Kondo M, Weissman IL, Akashi K. Identification of Clonogenic Common Lymphoid Progenitors in Mouse Bone Marrow. Nat Immunol. 1997;91:661–672. - PubMed
    1. Akashi K, Traver D, Miyamoto T, Weissman IL. A clonogenic common myeloid progenitor that gives rise to all myeloid lineages. Nature. 2000;404:193–197. - PubMed
    1. Hu M, Krause D, Greaves M, Sharkis S, Dexter M, Heyworth C, et al. Multilineage gene expression precedes commitment in the hemopoietic system. Genes & Development. 1997;11:774–785. - PubMed

Publication types

MeSH terms

Substances