Brucella genomics as we enter the multi-genome era

Abstract

The genus Brucella includes species considered among the worlds most important zoonotic pathogens, with brucellosis remaining a significant problem in large parts of the world. Over the last decade a number of Brucella genomes have been fully sequenced providing new insights into this relatively poorly understood group of organisms. In the forthcoming months and years, the availability of many additional genomes should help in further understanding of the evolution, host specificity and pathogenicity of this group as well as providing a resource to further improve epidemiological typing tools. This article describes progress to date and looks forward to the opportunities that should be afforded as we enter an era of multiple, freely available, Brucella genome sequences.