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Comment

. 2011 Sep 27;108(39):16143-4.

doi: 10.1073/pnas.1113312108. Epub 2011 Sep 19.

Resolving the role of prenatal sex steroids in the development of digit ratio

John T Manning¹

Affiliations

PMID: 21930921
PMCID: PMC3182713
DOI: 10.1073/pnas.1113312108

Comment

Resolving the role of prenatal sex steroids in the development of digit ratio

John T Manning. Proc Natl Acad Sci U S A. 2011.

. 2011 Sep 27;108(39):16143-4.

doi: 10.1073/pnas.1113312108. Epub 2011 Sep 19.

Author

John T Manning¹

Affiliation

¹ Department of Psychology, Swansea University, Swansea SA2 8PP, United Kingdom. j.manning@swansea.ac.uk

PMID: 21930921
PMCID: PMC3182713
DOI: 10.1073/pnas.1113312108

No abstract available

PubMed Disclaimer

Conflict of interest statement

The author declares no conflict of interest.

Figures

Fig. 1. — Fig. 1.
Causal links between PT, PE, and 2D:4D. As described by Zheng and Cohn (1), receptors for androgen and estrogen are present on digits 2 and 4 of the mouse but are most plentiful on the fourth digit. Chondrocyte proliferation is stimulated by PT but arrested by PE. Compared with females, males have higher levels of PT relative to PE and longer fourth digits relative to second digits. Thus, the sex difference in 2D:4D is dependent on prenatal changes in the fourth digit caused by sex-dependent differences in the PT-to-PE ratio. Examples of male and female human hands are shown for comparison.

See this image and copyright information in PMC

Comment on

Developmental basis of sexually dimorphic digit ratios.
Zheng Z, Cohn MJ. Zheng Z, et al. Proc Natl Acad Sci U S A. 2011 Sep 27;108(39):16289-94. doi: 10.1073/pnas.1108312108. Epub 2011 Sep 6. Proc Natl Acad Sci U S A. 2011. PMID: 21896736 Free PMC article.

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References

1. Zheng Z, Cohn MJ. Developmental basis of the sexually dimorphic digit ratio. Proc Natl Acad Sci USA. 2011;108:16289–16294. - PMC - PubMed
1. Peters M, Mackenzie K, Bryden P. Finger length and distal finger extent patterns in humans. Am J Phys Anthropol. 2002;117:209–217. - PubMed
1. Manning JT, Scutt D, Wilson J, Lewis-Jones DI. The ratio of 2nd to 4th digit length: A predictor of sperm numbers and concentrations of testosterone, luteinizing hormone and oestrogen. Hum Reprod. 1998;13:3000–3004. - PubMed
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1. Brown WM, Finn CJ, Breedlove SM. Sexual dimorphism in digit-length ratios of laboratory mice. Anat Rec. 2002;267:231–234. - PubMed

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