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Review
. 2011 Oct;21(10):1388-90.
doi: 10.1038/cr.2011.154. Epub 2011 Sep 20.

Mark the transition: chromatin modifications and cell fate decision

Qiang Wu  1 , Huck-Hui Ng
Affiliations
Review

Mark the transition: chromatin modifications and cell fate decision

Qiang Wu et al. Cell Res. 2011 Oct.
No abstract available

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Figures

Figure 1
Figure 1
Dynamic chromatin states in pluripotency and differentiation. (A) In undifferentiated hESCs, hESC-specific enhancers are marked by histone H3K4me1 and H3K27ac. Long-range chromatin interaction between the enhancer and the corresponding promoter within a CORD is mediated by hESC-specific transcription factor. The hESC-specific gene is expressed. (B) In DFCs, poised enhancers gain H3K27ac mark. Long-range chromatin interaction between the enhancer and the corresponding promoter within a CORD is mediated by DFC-specific transcription factor. This allows DFC-specific genes to be activated when hESCs are induced to differentiate.
See this image and copyright information in PMC

References

    1. Thomson JA, Itskovitz-Eldor J, Shapiro SS, et al. Embryonic stem cell lines derived from human blastocysts. Science. 1998;282:1145–1147. - PubMed
    1. Young RA. Control of the embryonic stem cell state. Cell. 2011;144:940–954. - PMC - PubMed
    1. Ng HH, Surani MA. The transcriptional and signalling networks of pluripotency. Nat Cell Biol. 2011;13:490–496. - PubMed
    1. Zhou VW, Goren A, Bernstein BE. Charting histone modifications and the functional organization of mammalian genomes. Nat Rev Genet. 2011;12:7–18. - PubMed
    1. Hawkins DR, Hon GC, Yang C, et al. Dynamic chromatin states in human ES cells reveal potential regulatory sequences and genes involved in pluripotency. Cell Res. 2011;21:1393–1409. - PMC - PubMed