doi: 10.1038/345783a0.
Direct and selective binding of an acidic transcriptional activation domain to the TATA-box factor TFIID
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- PMID: 2193231
- DOI: 10.1038/345783a0
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Direct and selective binding of an acidic transcriptional activation domain to the TATA-box factor TFIID
Nature.
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Abstract
The potent transactivation domain of the herpes simplex virion protein VP16 was used as a column ligand for affinity chromatography. VP16 binds strongly and highly selectively to the human and yeast TATA box-binding factors. Our results imply that the principal target for acidic activation domains is the TATA-box factor TFIID.
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