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. 1990 Jun 28;345(6278):783-6.
doi: 10.1038/345783a0.

Direct and selective binding of an acidic transcriptional activation domain to the TATA-box factor TFIID

K F Stringer  1 , C J Ingles, J Greenblatt
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Direct and selective binding of an acidic transcriptional activation domain to the TATA-box factor TFIID

K F Stringer et al. Nature. .

Abstract

The potent transactivation domain of the herpes simplex virion protein VP16 was used as a column ligand for affinity chromatography. VP16 binds strongly and highly selectively to the human and yeast TATA box-binding factors. Our results imply that the principal target for acidic activation domains is the TATA-box factor TFIID.

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