[Circumannular features of non-specific resistance in patients with osteoarthrosis in mid-lattitudes]

Abstract

Modified cosinor-analysis was used to calculate biorhythmologic characteristics (period, amplitude, phase, mesor) of the circumannual rhythm of neuroendocrine regulation parameters, the state of bioradical hemostasis, and protein components of non-specific resistance in patients with osteoarthrosis living in moderate climates. Near-annual rhythms of these parameters are described. The chronological analysis indicates that strenuouos activity of the regulatory systems responsible for adaptive reactions of the organism falls within the periods from March to May and from August to October. Variability of the above parameters is shown to be related to the efficacy of osteoarthrosis therapy in different phases of the near-annual rhythm.