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Review
. 2012 Jan;52(1):152-64.
doi: 10.1016/j.advenzreg.2011.09.005.

Phospholipase C signaling and calcium influx

James W Putney  1 , Takuro Tomita
Affiliations
Review

Phospholipase C signaling and calcium influx

James W Putney et al. Adv Biol Regul. 2012 Jan.
No abstract available

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Figures

Figure
Figure
Agonist (Ag) activation of a receptor (R) leads to activation of phospholipase C (PLC), in some instances through an intermediate G protein (G) resulting in the release of IP3, formation of diacylglycerol (DAG) and a decrease in PIP2. IP3 activates an IP3 receptor (IP3R) on the endoplasmic reticulum resulting in release of stored Ca2+. The drop in endoplasmic reticulum Ca2+ activates a Ca2+ sensor, STIM1, that redistributes within the endoplasmic reticulum to sites where it can interact with and activate the store-operated Orai1 Ca2+-selective channels. Another class of less selective, Ca2+-permeable channels, the TRPCs, are activated by PLC, most likely by changes in membrane composition of DAG and PIP2. Some TRPC channels are inhibited by protein kinase C and/or require the tyrosine kinase, src. Not shown in this figure is a presumed complex interaction between the pathways involving the translocation of TRPC channels to the membrane in response to Ca2+ entering through Orai1 channels (see (Cheng et al., 2011)).
See this image and copyright information in PMC

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References

    1. Abdullaev IF, Bisaillon JM, Potier M, Gonzalez JC, Motiani RK, Trebak M. Stim1 and Orai1 Mediate CRAC Currents and Store-Operated Calcium Entry Important for Endothelial Cell Proliferation. Circ Res. 2008;103:1289–1299. - PMC - PubMed
    1. Abramowitz J, Birnbaumer L. Physiology and pathophysiology of canonical transient receptor potential channels. FASEB J. 2008 - PMC - PubMed
    1. Acharya JK, Jalink K, Hardy RW, Hartenstein V, Zuker CS. InsP3 receptor is essential for growth and differentiation but not for vision in Drosophila. Neuron. 1997;18:881–887. - PubMed
    1. Ambudkar IS, Ong HL. Organization and function of TRPC channelosomes. Pflugers Arch. 2007 - PubMed
    1. Baba Y, Kurosaki T. Physiological function and molecular basis of STIM1-mediated calcium entry in immune cells. Immunol Rev. 2009;231:174–188. - PubMed

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