Does protein phosphorylation play a role in translational control by eukaryotic aminoacyl-tRNA synthetases?

Abstract

In addition to their primary role in tRNA charging, aminoacyl-tRNA synthetases can regulate protein synthesis in eukaryotic cells. Although the phosphorylation of these enzymes themselves has little effect on their catalytic activity, there may be a role for protein phosphorylation in mediating their regulatory effects.