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Review
. 1990 May;15(5):186-90.
doi: 10.1016/0968-0004(90)90159-9.

The where, what and how of ribosomal frameshifting in retroviral protein synthesis

D Hatfield  1 , S Oroszlan
Affiliations
Review

The where, what and how of ribosomal frameshifting in retroviral protein synthesis

D Hatfield et al. Trends Biochem Sci. 1990 May.

Abstract

The gag and pol genes of most retroviruses occur in different reading frames and their translation as a single polypeptide is carried out by ribosomal frameshifting in the -1 direction. The alignment of the different reading frames occurs by overlapping reading in response to at least two signals within the RNA: one is a heptanucleotide stretch at the frameshift site and the other is a stem-loop structure which occurs just downstream of the first signal.

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