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Review
. 1990 May;15(5):202-7.
doi: 10.1016/0968-0004(90)90163-6.

Through the looking glass: the discovery of supercoiled DNA

J Lebowitz  1
Affiliations
Review

Through the looking glass: the discovery of supercoiled DNA

J Lebowitz. Trends Biochem Sci. 1990 May.

Abstract

The discovery of supercoiled DNA was first reported 25 years ago in a paper entitled, 'The Twisted Circular Form of Polyoma Viral DNA' by Vinograd, Lebowitz, Radloff, Watson and Laipis. This personal reflection describes the different experimental and conceptual processes that eventually led to the discovery as they actually occurred.

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