ASCertaining cytoskeletal rearrangements in antigen presentation and migration
- PMID: 21934669
- DOI: 10.1038/ni.2114
ASCertaining cytoskeletal rearrangements in antigen presentation and migration
Erratum in
- Nat Immunol. 2013 Aug;14(8):876
Abstract
ASC has emerged as an adaptor for inflammasome sensors in cells of the innate immune response. New inflammasome-independent roles have been identified for ASC in the control of adaptive immunity; these include the post-transcriptional regulation of cytoskeletal rearrangements.
Comment on
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The inflammasome adaptor ASC regulates the function of adaptive immune cells by controlling Dock2-mediated Rac activation and actin polymerization.Nat Immunol. 2011 Sep 4;12(10):1010-6. doi: 10.1038/ni.2095. Nat Immunol. 2011. PMID: 21892172 Free PMC article.
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