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Review
. 2011 Sep 20;12(10):933-40.
doi: 10.1038/ni.2094.

Malignant pirates of the immune system

Lixin Rui  1 , Roland Schmitz, Michele Ceribelli, Louis M Staudt
Affiliations
Review

Malignant pirates of the immune system

Lixin Rui et al. Nat Immunol. .

Abstract

At great human cost, cancer is the largest genetic experiment ever conducted. This review highlights how lymphoid malignancies have genetically perverted normal immune signaling and regulatory mechanisms for their selfish oncogenic goals of unlimited proliferation, perpetual survival and evasion of the immune response.

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