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Comment
. 2011 Oct;90(4):493-5.
doi: 10.1038/clpt.2011.187. Epub 2011 Aug 10.

The impact of pharmacogenomics on the management of cardiac disease

N L Pereira  1 , R M Weinshilboum
Affiliations
Comment

The impact of pharmacogenomics on the management of cardiac disease

N L Pereira et al. Clin Pharmacol Ther. 2011 Oct.

Abstract

Pharmacogenomics promises to help maximize efficacy and minimize adverse drug reactions. It could have a significant impact on the treatment of cardiovascular disease, the leading cause of death in the United States. The past decade has seen pharmacogenomics move from study of a candidate gene to genome-wide approaches, with the development of a series of pharmacogenetic tests. However, many barriers need to be overcome for cardiovascular pharmacogenomics to have its promised clinical impact.

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Conflict of interest statement

CONFLICT OF INTEREST

The authors declared no conflict of interest.

Figures

Figure 1
Figure 1
Adjusted hospitalization rates: intention-to-treat analysis. The figure shows the hospitalization rate for patients in each study group during the 6-month period following initiation of warfarin treatment. (a) Events due to any cause; (b) events due to bleeding or thromboembolism. CI, confidence interval; HC, historical control; HR, hazard ratio; IG, intervention group. Reprinted with permission from ref. .
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