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. 2011 Aug;36(8):733-8.
doi: 10.3969/j.issn.1672-7347.2011.08.006.

Brain function of heroin addicts after withdrawal

Xuyi Wang  1 , Xuhui Zhou, Yanhui Liao, Jinsong Tang, Tieqiao Liu, Wei Hao
Affiliations

Brain function of heroin addicts after withdrawal

Xuyi Wang et al. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2011 Aug.

Abstract

Objective: To explore what brain regions are modulated by heroin addiction and withdrawal.

Methods: We used functional magnetic resonance imaging to investigate the brain function in 15 heroin-dependent patients 3 days (acute) and 1 month (protracted) after heroin abstinence. Sixteen normal controls were included.

Results: The blood oxygen level-dependent signal in the orbitofrontal cortex of the brain of heroin-dependent patients was significantly elevated 3 days after the withdrawal. Hyperfunction of the orbitofrontal cortex declined 1 month after the withdrawal.

Conclusion: Heroin-dependent subjects at both 3 days and 1 month abstinence have persistent abnormalities in the brain function. Although some tangible beneficial effects are noted following 1 month of detoxification, possible permanent damage to the brain caused by heroin use is suggested.

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