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. 1990;28(1):27-34.
doi: 10.1080/02681219080000041.

Pathogenicity of 5-fluorocytosine resistant strains of Candida albicans

M O Fasoli  1 , D Kerridge, J F Ryley
Affiliations

Pathogenicity of 5-fluorocytosine resistant strains of Candida albicans

M O Fasoli et al. J Med Vet Mycol. 1990.

Abstract

Mutants of Candida albicans blocked in pyrimidine transport and salvage metabolism were produced by a two step mutagenic procedure and selected by their resistance to 5-fluorocytosine (flucytosine). The growth rates and growth yields of these mutants did not differ significantly from the parental strain of C. albicans. Examination of their pathogenicity to mice demonstrated that a defect in the uridine transport function decreased the pathogenicity of C. albicans.

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