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. 2011 Nov;49(11):3994-6.
doi: 10.1128/JCM.05349-11. Epub 2011 Sep 21.

Molecular epidemiology of Clostridium difficile strains in children compared with that of strains circulating in adults with Clostridium difficile-associated infection

Nicole Stoesser  1 , Derrick W Crook, Rowena Fung, David Griffiths, Rosalind M Harding, Melina Kachrimanidou, Satish Keshav, Tim E Peto, Alison Vaughan, A Sarah Walker, Kate E Dingle
Affiliations

Molecular epidemiology of Clostridium difficile strains in children compared with that of strains circulating in adults with Clostridium difficile-associated infection

Nicole Stoesser et al. J Clin Microbiol. 2011 Nov.

Abstract

Molecular analysis of Clostridium difficile (28 isolates) from children (n = 128) in Oxfordshire, United Kingdom, identified eight toxigenic genotypes. Six of these were isolated from 27% of concurrent adult C. difficile-associated infections studied (n = 83). No children carried hypervirulent PCR ribotype 027. Children could participate in the transmission of some adult disease-causing genotypes.

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Figures

Fig. 1.
Fig. 1.
Distribution of STs in children and adults with CDI as a proportion of the total number of isolates in each group (1 November 2008 to 1 February 2009). Asymptomatic or symptomatic refers to the absence or presence of diarrhea, respectively. Asterisks denote STs identified in children in this study that were nontoxigenic in this group. A− B+ isolates were exclusively ST-37.
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