[Genetic basis for construction of the life influenza type A vaccine using temperature-sensitive mutants]

Abstract

Published data and authors' original material on the use of temperaturesensitive influenza virus mutants (ts) as donors in attenuation process aimed at obtaining the recombinant live influenza vaccines (LIV) are reviewed. The so called cold adapted ts donors are shown to be superior for this aim. The data are presented in the review on the association of the mutations in the genome of cold adapted donors with attenuation, on the reactivity, immunogenicity and genetical stability of the recombinant LIVs constructed on the basis of the cold adapted donors.