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. 2012:2012:869841.
doi: 10.1155/2012/869841. Epub 2011 Sep 20.

CD4 Cell Counts at HIV Diagnosis among HIV Outpatient Study Participants, 2000-2009

Kate Buchacz  1 , Carl Armon, Frank J Palella, Rose K Baker, Ellen Tedaldi, Marcus D Durham, John T Brooks
Affiliations

CD4 Cell Counts at HIV Diagnosis among HIV Outpatient Study Participants, 2000-2009

Kate Buchacz et al. AIDS Res Treat. 2012.

Abstract

Background. It is unclear if CD4 cell counts at HIV diagnosis have improved over a 10-year period of expanded HIV testing in the USA. Methods. We studied HOPS participants diagnosed with HIV infection ≤6 months prior to entry into care during 2000-2009. We assessed the correlates of CD4 count <200 cells/mm(3) at HIV diagnosis (late HIV diagnosis) by logistic regression. Results. Of 1,203 eligible patients, 936 (78%) had a CD4 count within 3 months after HIV diagnosis. Median CD4 count at HIV diagnosis was 299 cells/mm(3) and did not significantly improve over time (P = 0.13). Comparing periods 2000-2001 versus 2008-2009, respectively, 39% and 35% of patients had a late HIV diagnosis (P = 0.34). Independent correlates of late HIV diagnosis were having an HIV risk other than being MSM, age ≥35 years at diagnosis, and being of nonwhite race/ethnicity. Conclusions. There is need for routine universal HIV testing to reduce the frequency of late HIV diagnosis and increase opportunity for patient- and potentially population-level benefits associated with early antiretroviral treatment.

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Figures

Figure 1
Figure 1
CD4 cell count (cells/mm3) by period of HIV diagnosis, the HIV Outpatient Study 2000–2009 (N = 936).
See this image and copyright information in PMC

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