Clinical response to Auron Misheil Therapy in a man with advanced multifocal hepatocellular carcinoma: A case report

Abstract

Introduction: Auron Misheil Therapy was developed based on similarities between carcinogenesis and inflammation. Auron Misheil Therapy is a combination of natural and synthetic compounds, including anti-inflammatory drugs and insulin, expected to exhibit synergistic effects.

Case presentation: Here, we report the case of a 78-year-old Caucasian male patient who presented with multifocal hepatocellular carcinoma and chronic hepatitis C virus infection. Over a four-year period our patient was treated with radiofrequency ablation and transarterial chemoembolization. After these treatments there was tumor progression, with new hyperperfused lesions without evidence of extrahepatic tumor involvement. Our patient refused sorafenib therapy. Therefore, he received twice daily intramuscular injections of Auron Misheil Therapy on an outpatient basis for two months. Partial remission of the hepatic lesions was observed eight weeks after the start of treatment, and confirmed four weeks later. Unfortunately, at that time our patient refused therapy due to dizziness. During follow-up two target lesions remained stable, but one lesion increased in size. At the latest follow-up, one year later, there was still tumor control.

Conclusion: While the mechanisms underlying the antitumor effects of Auron Misheil Therapy are not fully understood, stable disease and remissions have been observed in different types of tumors, including hepatocellular carcinoma.

Figure 1

Baseline CT abdomen scan. Early arterial examination time, showing liver cirrhosis after transarterial chemoembolization with hypotrophy of his right liver lobe and hypertrophy of his left liver lobe. Lipiodol remnants in the right lobe. Arrow: TL1 in segment 8, size 20 mm.

Figure 2

Control CT abdomen scan after eight weeks of AMT treatment. Early arterial examination time, showing liver cirrhosis after transarterial chemoembolization. TL1 disappeared.

Figure 3

Follow up CT scan six months later. Early arterial examination time scan revealing recurrence of TL3, size 11 mm (arrow) and a new lesion next to a cyst of size 12 mm in liver segment 4b (arrow head).