Excitable T cells: Ca(v)1.4 channel contributions and controversies
- PMID: 21943485
- DOI: 10.1016/j.immuni.2011.09.001
Excitable T cells: Ca(v)1.4 channel contributions and controversies
Abstract
Store-operated CRAC channels encoded by the Orai genes mediate calcium entry in T cells. In this issue of Immunity, Omilusik et al. (2011) record Ca(V)1.4-mediated voltage-gated calcium currents in T cells and address their role for T cell development and function.
Copyright © 2011 Elsevier Inc. All rights reserved.
Comment on
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The Ca(v)1.4 calcium channel is a critical regulator of T cell receptor signaling and naive T cell homeostasis.Immunity. 2011 Sep 23;35(3):349-60. doi: 10.1016/j.immuni.2011.07.011. Epub 2011 Aug 11. Immunity. 2011. PMID: 21835646
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