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Comparative Study
. 1990 Jun 15;268(3):795-7.
doi: 10.1042/bj2680795.

Protein turnover is elevated in muscle of mdx mice in vivo

P A MacLennan  1 , R H Edwards
Affiliations
Comparative Study

Protein turnover is elevated in muscle of mdx mice in vivo

P A MacLennan et al. Biochem J. .

Abstract

mdx mice lack the protein dystrophin, the absence of which causes Duchenne muscular dystrophy in humans. To examine how mdx mice maintain muscle mass despite dystrophin deficiency, we measured protein turnover rates in muscles of mdx and wild-type (C57BL/10) mice in vivo. At all ages studied, rates of muscle protein synthesis and degradation were higher in mdx than in C57BL/10 mice.

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