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. 1990 May 21;516(2):354-6.
doi: 10.1016/0006-8993(90)90942-5.

S-100B but not NGF, EGF, insulin or calmodulin is a CNS serotonergic growth factor

E C Azmitia  1 , K Dolan, P M Whitaker-Azmitia
Affiliations
Free article

S-100B but not NGF, EGF, insulin or calmodulin is a CNS serotonergic growth factor

E C Azmitia et al. Brain Res. .
Free article

Abstract

The effects of S-100B, nerve growth factor (NGF), epidermal growth factor (EGF) and insulin were tested in cultured mesencephalic neurons. Only chronic S-100B showed enhancement (maximal at 3.2 ng/ml is 171%) after 3 days of incubation of the [3H]5-HT uptake capacity by serotonergic neurons. A single application at initial plating of S-100B (maximal at 5 ng/ml is 185%), but not calmodulin, increased the development of the [3H]5-HT uptake capacity by the cultured serotonergic neurons. Morphometric analysis of cultured 5-HT immunoreactive (IR) neurons showed an increase (135 and 147%) in neurite length 30 h after S-100B application of 16 and 3.2 ng/ml (respectively). These results suggest that S-100B is a serotonergic growth factor in the mammalian brain.

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