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Comment
. 2011 Oct 1;10(19):3234-5.
doi: 10.4161/cc.10.19.17127. Epub 2011 Oct 1.

Checking before changing: cell cycle checkpoints inhibit muscle differentiation

Jean Y J Wang  1
Affiliations
Comment

Checking before changing: cell cycle checkpoints inhibit muscle differentiation

Jean Y J Wang. Cell Cycle. .
No abstract available

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Figures

Figure 1
Figure 1
DNA damage-induced muscle differentiation checkpoints. Genotoxins activate two differentiation checkpoints at G1/S and G2/M to inhibit MyoD-dependent muscle gene expression in DNA damaged myoblasts. These checkpoints are reversible, as differentiation can resume after DNA is repaired. Inhibition of MyoD (depicted as the small green cylinder) is mediated by the cell cycle checkpoints, because inhibitors of the G1/S or G2/M cell cycle arrest, i.e., IGF1 or caffeine, also block the differentiation/arrest, respectively. In G1/S-arrested myoblasts, MyoD remains associated with the promoters of muscle-specific genes but does not stimulate transcription. In G2/M-arrested myoblasts, MyoD dissociates from DNA and is thus unable to stimulate muscle-specific gene expression.
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