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Case Reports
. 2012 Jun;6(2):250-4.
doi: 10.1007/s12105-011-0301-z. Epub 2011 Sep 25.

Colonic-type adenocarcinoma of the base of the tongue: a case report of a rare neoplasm

Denisa Slova  1 , Alberto Paniz Mondolfi, Ioana Moisini, Gabriel Levi, Mark Urken, Jose Zevallos, Sharmeen Mansoor, Azita Khorsandi, Dov Bloch, Ramapriya Vidhun, Bruce Wenig
Affiliations
Case Reports

Colonic-type adenocarcinoma of the base of the tongue: a case report of a rare neoplasm

Denisa Slova et al. Head Neck Pathol. 2012 Jun.

Abstract

Lingual adenocarcinomas (ADC), either primary or metastatic to the tongue are extraordinarily rare neoplasms. Primary lingual adenocarcinomas are primarily of minor salivary gland origin. Two cases of primary colonic-type adenocarcinomas of the base of the tongue were recently reported for the first time in the English literature. We present an additional case of lingual intestinal-type adenocarcinoma with mucinous features that occurred in association with cervical node metastasis and discuss the clinicopathologic features and histogenetic aspects of this rare entity.

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Figures

Fig. 1
Fig. 1
a Axial and coronal fat suppressed images demonstrate a multilobular midline rim enhancing and centrally necrotic oral tongue lesion (arrow). b The tumor (center) was resected through a median mandibulolabioglossotomy approach
Fig. 2
Fig. 2
a Colonic type adenocarcinoma with mucinous differentiation, low power. Unremarkable squamous epithelial lining with focal surface ulceration, underlying tubulo-glandular and mucinous adenocarcinomatous components. b Tubulo-glandular component showing pseudostratification and loss of polarity, medium power (20×). c Variably sized mucin pools separated by fibrous septa with tumor cells floating individually and/or in clusters, medium power (20×). d The floating tumor cells show increase in the nuclear-to-cytoplasmic ratio with intermediate grade nuclei and eosinophilic cytoplasm, high power (40×). e Right neck lymph node involved by metastatic colonic type adenocarcinoma, (whole mount)
Fig. 3
Fig. 3
a CK7—strong membranous and cytoplasmic staining. b CK20—moderate membranous and cytoplasmic staining. c CDX-2 showing strong nuclear staining. d Villin—strong cytoplasmic staining
See this image and copyright information in PMC

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