Galectins as pattern recognition receptors: structure, function, and evolution
- PMID: 21948360
- PMCID: PMC3429938
- DOI: 10.1007/978-1-4614-0106-3_2
Galectins as pattern recognition receptors: structure, function, and evolution
Abstract
Galectins constitute an evolutionary conserved family of ß-galactoside-binding proteins, ubiquitous in mammals and other vertebrate taxa, invertebrates, and fungi. Since their discovery in the 1970s, their biological roles, initially understood as limited to recognition of carbohydrate ligands in embryogenesis and development, have expanded in recent years by the discovery of their immunoregulatory activities. A gradual paradigm shift has taken place in the past few years through the recognition that galectins also bind glycans on the surface of potentially pathogenic microbes, and function as recognition and effector factors in innate immunity. Further, an additional level of functional complexity has emerged with the most recent findings that some parasites "subvert" the recognition roles of the vector/host galectins for successful attachment or invasion.
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References
-
- Ahmed H, Vasta GR. Galectins: conservation of functionally and structurally relevant amino acid residues defines two types of carbohydrate recognition domains. Glycobiology. 1994;4:548. - PubMed
-
- Ahmed H, Bianchet MA, Amzel LM, Hirabayashi J, Kasai KI, Giga-Hama Y, Tohda H, Vasta GR. Novel carbohydrate specificity of the 16-kDa galectin from Caenorhabditis elegans: binding to blood group precursor oligosaccharides (type 1, type 2, Talpha, and Tbeta) and gangliosides. Glycobiology. 2002;12:461. - PubMed
-
- Ahmed H, Du SJ, O’Leary N, Vasta GR. Biochemical and molecular characterization of galectins from zebrafish (Danio rerio): notochord-specific expression of a prototype galectin during early embryogenesis. Glycobiology. 2004;14:232. - PubMed
-
- Bianchet MA, Ahmed H, Vasta GR, Amzel LM. Soluble beta-galactosyl-binding lectin (galectin) from toad ovary: crystallographic studies of two protein-sugar complexes. Proteins. 2000;40:388. - PubMed
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