Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2011:2011:208940.
doi: 10.1155/2011/208940. Epub 2011 Aug 28.

Bipartite anterior extraperitoneal teratoma: evidence for the embryological origins of teratomas?

D J B Keene  1 , R J Craigie, A Shabani, G Batra, S Hennayake
Affiliations
Case Reports

Bipartite anterior extraperitoneal teratoma: evidence for the embryological origins of teratomas?

D J B Keene et al. Case Rep Med. 2011.

Abstract

Teratomas are thought to arise from totipotent primordial germ cells (PGCs) Dehner (1983) which may miss their target destination Moore and Persaud (1984). Teratomas can occur anywhere from the brain to the coccygeal area but are usually in the midline close to the embryological position of the gonadal ridges Bale (1984), Nguyen and Laberge (2000). We report a case of a bipartite anterior extraperitoneal teratoma. This is an unusual position for a teratoma, but one which may support the "missed target" theory of embryology.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Prominent mass lower abdomen.
Figure 2
Figure 2
T2 coronal section of fat-suppressed abdominal magnetic resonance scan showing different signal intensities in solid component (A) and high signal in cystic component (B).
Figure 3
Figure 3
T1 transverse section of abdominal magnetic resonance scan showing intermediate signal in solid component (A) with low signal areas representing calcification and low signal in cystic component (B).
Figure 4
Figure 4
Cystic component of mass. (a) Macroscopic appearance of fresh unfixed specimen. (b) Macroscopic appearance of fixed specimen with cyst opened. (c) Microscopy of haematoxalin and eosin-stained specimen at x2.5 magnification. Layers of enteric lined mucosa comprising of columnar epithelia (E), submucosa (S), and muscularis (M).
Figure 5
Figure 5
Solid component of mass stained with haematoxalin and eosin. (a) Macroscopic appearance of fresh unfixed specimen. (b) Microscopy x10 magnification. Osteoblast layer on the surface of bone (B) adjacent to cartilage (C). (c) Microscopy x20 magnification. Skeletal muscle fibres (M), nerve (N), and fat (F). (d) Microscopy x10 magnification. Nerve cells (N), ganglion (G), fat (F) and, epithelia lined cyst (E). (e) Microscopy x20 magnification. Pilosebaceous unit comprising of sebaceous gland (SG), hair follicle (HF), hair (H). (f) Plain X-ray of solid component showing skeletal structure.
Figure 6
Figure 6
Migrational theory of primordial germ cells [4]. Reproduced by permission of Elsevier Saunders.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Dehner LP. Gonadal and extragonadal germ cell neoplasia of childhood. Human Pathology. 1983;14(6):493–511. - PubMed
    1. Moore K, Persaud T. The Developing Human. Philadelphia, Pa, USA: WB Saunders; 1993.
    1. Bale PM. Sacrococcygeal developmental abnormalities and tumors in children. Perspectives in Pediatric Pathology. 1984;8(1):9–56. - PubMed
    1. Nguyen LT, Laberge J-M. Teratomas, dermoids and other soft tissue tumors. In: Ashcraft KW, editor. Pediatric Surgery. Philadelphia, Pa, USA: Saunders; 2000. pp. 972–974.
    1. de Lagausie P, de Napoli SC, Stempfle N, et al. Highly differentiated teratoma and fetus-in-fetu: a single pathology? Journal of Pediatric Surgery. 1997;32(1):115–116. - PubMed

Publication types

LinkOut - more resources