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Review
. 2011 Oct;17(5):577-84.
doi: 10.1111/j.1755-5949.2011.00264.x.

From hypertension to stroke: mechanisms and potential prevention strategies

Jian-Guang Yu  1 , Rui-Rui Zhou, Guo-Jun Cai
Affiliations
Review

From hypertension to stroke: mechanisms and potential prevention strategies

Jian-Guang Yu et al. CNS Neurosci Ther. 2011 Oct.

Abstract

Stroke is a major cause of disability and death worldwide. Prevention aimed at risk factors of stroke is the most effective strategy to curb the stroke pandemic. Hypertension is one of the most important risk factors for stroke. Despite the substantial evidence of the benefits of lowering blood pressure, conventional treatment does not normalize the burden of major cardiovascular events in patients with hypertension. Fully understanding the factors involved in the hypertension-induced stroke helps to develop new strategies for stroke prevention. Antihypertensive therapies selected should have positive blood pressure-independent effects on stroke risk. This review summarizes the factors involved in the hypertension-induced stroke, such as oxidative stress, inflammation, and arterial baroreflex dysfunction, and potential strategies for its prevention, therefore, provides clues for clinicians.

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Conflict of interest statement

The authors have no conflict of interest.

Figures

Figure 1
Figure 1
Mechanisms by which hypertension induces stroke.
See this image and copyright information in PMC

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