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Review
. 2011 Oct 10;50(42):9794-824.
doi: 10.1002/anie.201101960. Epub 2011 Sep 27.

Regio- and chemoselective metalation of arenes and heteroarenes using hindered metal amide bases

Benjamin Haag  1 , Marc Mosrin, Hiriyakkanavar Ila, Vladimir Malakhov, Paul Knochel
Affiliations
Review

Regio- and chemoselective metalation of arenes and heteroarenes using hindered metal amide bases

Benjamin Haag et al. Angew Chem Int Ed Engl. .

Abstract

The preparation of highly functionalized organometallic compounds can be achieved by direct C-H activation of a broad range of unsaturated substrates using lithium chloride solubilized 2,2,6,6-tetramethylpiperidide bases (TMP(n)MX(m)⋅p LiCl). These are excellent reagents for converting a wide range of aromatic and heterocyclic substrates into valuable organometallic reagents with broad applications in organic synthesis.

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