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. 2011 Oct;26(12):2283-6.
doi: 10.1002/mds.23934. Epub 2011 Sep 23.

Association of SNCA with Parkinson: replication in the Harvard NeuroDiscovery Center Biomarker Study

Hongliu Ding  1 , Alison K Sarokhan, Sarah S Roderick, Rachit Bakshi, Nancy E Maher, Paymon Ashourian, Caroline G Kan, Sunny Chang, Andrea Santarlasci, Kyleen E Swords, Bernard M Ravina, Michael T Hayes, U Shivraj Sohur, Anne-Marie Wills, Alice W Flaherty, Vivek K Unni, Albert Y Hung, Dennis J Selkoe, Michael A Schwarzschild, Michael G Schlossmacher, Lewis R Sudarsky, John H Growdon, Adrian J Ivinson, Bradley T Hyman, Clemens R Scherzer
Affiliations

Association of SNCA with Parkinson: replication in the Harvard NeuroDiscovery Center Biomarker Study

Hongliu Ding et al. Mov Disord. 2011 Oct.

Abstract

Background: Mutations in the α-synuclein gene (SNCA) cause autosomal dominant forms of Parkinson's disease, but the substantial risk conferred by this locus to the common sporadic disease has only recently emerged from genome-wide association studies.

Methods: We genotyped a prioritized noncoding variant in SNCA intron 4 in 344 patients with Parkinson's disease and 275 controls from the longitudinal Harvard NeuroDiscovery Center Biomarker Study.

Results: The common minor allele of rs2736990 was associated with elevated disease susceptibility (odds ratio, 1.40; P = .0032).

Conclusions: This result increases confidence in the notion that in many clinically well-characterized patients, genetic variation in SNCA contributes to "sporadic" disease.

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