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. 2011 Nov;38(11):889-92.
doi: 10.1111/j.1600-0560.2011.01779.x.

Hypertrophic lupus erythematosus: the diagnostic utility of CD123 staining

Christine J Ko  1 , Bhaskar Srivastava, Irwin Braverman, Richard J Antaya, Jennifer M McNiff
Affiliations

Hypertrophic lupus erythematosus: the diagnostic utility of CD123 staining

Christine J Ko et al. J Cutan Pathol. 2011 Nov.

Abstract

CD123-positive plasmacytoid dendrocytes are prominent in the infiltrate of discoid lupus erythematosus (LE). We hypothesized that these cells would also be present in hypertrophic LE and would aid in the histopathologic distinction from squamous cell carcinoma (SCC) and hypertrophic actinic keratosis (AK). Five cases of hypertrophic LE and 10 cases each of SCC and hypertrophic AK were stained with CD123. A heavy band of CD123-positive cells was present at the epidermal-dermal junction in all cases of hypertrophic LE, and only single or rare scattered clusters of CD123-positive cells were seen in SCC and actinic keratoses. The pattern of CD123 staining can be a useful feature to distinguish hypertrophic LE from SCC and hypertrophic AK.

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Figures

Fig. 1
Fig. 1
The index patient had keratoacanthoma-like lesions of hypertrophic lupus erythematosus appear in crops over his sun-damaged arms and hands. In panel (A), a crop of lesions is seen. Panel (B) shows partial resolution of the lesions at 1 month after injection of 10 mg/cc intralesional triamcinolone. Panel (C) shows further resolution of the lesions at 8 months time.
Fig. 2
Fig. 2
Hypertrophic lupus erythematosus with pseudocarcinomatous hyperplasia. There is basal vacuolar change, cytologicatypia limited to the periphery of epidermal buds and a lichenoid inflammatory infiltrate.
Fig. 3
Fig. 3
A heavy band of CD123-positive cells is present beneath the epidermis.
Fig. 4
Fig. 4
Scattered cells with CD123-positivity in this hypertrophic actinic keratosis.
See this image and copyright information in PMC

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