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. 2011 Dec;96(12):E2018-22.
doi: 10.1210/jc.2011-1497. Epub 2011 Sep 28.

The roles of IL-6, IL-10, and IL-1RA in obesity and insulin resistance in African-Americans

Bashira A Charles  1 , Ayo Doumatey, Hanxia Huang, Jie Zhou, Guanjie Chen, Daniel Shriner, Adebowale Adeyemo, Charles N Rotimi
Affiliations

The roles of IL-6, IL-10, and IL-1RA in obesity and insulin resistance in African-Americans

Bashira A Charles et al. J Clin Endocrinol Metab. 2011 Dec.

Abstract

Objective: The aim of the study was to investigate the associations between IL-1 receptor antagonist (IL-1RA), IL-6, IL-10, measures of obesity, and insulin resistance in African-Americans.

Research design and methods: Nondiabetic participants (n = 1025) of the Howard University Family Study were investigated for associations between serum IL (IL-1RA, IL-6, IL-10), measures of obesity, and insulin resistance, with adjustment for age and sex. Measures of obesity included body mass index, waist circumference, hip circumference, waist-to-hip ratio, and percent fat mass. Insulin resistance was assessed using the homeostasis model assessment of insulin resistance (HOMA-IR). Data were analyzed with R statistical software using linear regression and likelihood ratio tests.

Results: IL-1RA and IL-6 were associated with measures of obesity and insulin resistance, explaining 4-12.7% of the variance observed (P values < 0.001). IL-1RA was bimodally distributed and therefore was analyzed based on grouping those with low vs. high IL-1RA levels. High IL-1RA explained up to 20 and 12% of the variance in measures of obesity and HOMA-IR, respectively. Among the IL, only high IL-1RA improved the fit of models regressing HOMA-IR on measures of obesity. In contrast, all measures of obesity improved the fit of models regressing HOMA-IR on IL. IL-10 was not associated with obesity measures or HOMA-IR.

Conclusions: High IL-1RA levels and obesity measures are associated with HOMA-IR in this population-based sample of African-Americans. The results suggest that obesity and increased levels of IL-1RA both contribute to the development of insulin resistance.

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