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. 1979 Mar;27(3):171-4.
doi: 10.1097/00007890-197903000-00006.

Prolongation of islet allograft survival

Prolongation of islet allograft survival

P E Lacy et al. Transplantation. 1979 Mar.

Abstract

Pretreatment of donor rats with irradiation and silica followed by in vitro culture of the islets for 1 to 2 days prolonged survival of allografts across a minor histocompatibility barrier if "hand-picked," clean islets were used for transplantation. Pretreatment of donor rats with irradiation and silica in conjunction with a single injection of antilymphocyte serum (ALS) into the recipient produced a prolongation of survival of hand-picked islets transplanted across a major histocompatibility barrier.

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