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. 2011 Jul;5(3):289-94.
doi: 10.4103/1658-354X.84104.

Intra and postoperative outcome of adding clonidine to bupivacaine in infraorbital nerve block for young children undergoing cleft lip surgery

Parul Jindal  1 , Gurjeet Khurana, Sanjay Dvivedi, J P Sharma
Affiliations

Intra and postoperative outcome of adding clonidine to bupivacaine in infraorbital nerve block for young children undergoing cleft lip surgery

Parul Jindal et al. Saudi J Anaesth. 2011 Jul.

Abstract

AIMS AND CONTEXT: To evaluate the efficacy of adding clonidine to bupivacaine in bilateral infraorbital nerve block for hemodynamic changes, requirement of opioids, volatile agent, and muscle relaxants intraoperatively and relief of pain postoperatively

Setting and design: Prospective, randomized, double-blind study.

Methods: Fifty pediatric patients aged less than 24 months undergoing elective cleft lip repair were randomly allocated to two groups of 25 each. After tracheal intubation, group A received bilateral infraorbital nerve block with 1 ml solution of clonidine (1 μg/kg) and bupivacaine 0.25%, and group B received 1 ml of 0.25% bupivacaine. Hemodynamic parameters, intraoperative requirement of volatile anesthetic agent, muscle relaxant, and analgesic were recorded. Pain was assessed postoperatively using the Face, Legs, Activity, Cry, Consolability scale till the first rescue drug was given.

Statistical analysis: Two sample unpaired t-test and the correlation r test.

Results: The duration of analgesia from the time of administration of block in group A was 667.72 ± 210.74 min compared to 558.48 ± 150.28 min in group B (P<0.05).

Conclusion: Addition of clonidine as an adjunct to local anesthetic significantly decreased the requirement of other anesthetic drugs and significantly prolonged the duration of postoperative analgesia without any adverse effects.

Keywords: Cleft lip surgery; clonidine; infraorbital nerve block.

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Conflict of interest statement

Conflict of Interest: None declared.

Figures

Figure 1
Figure 1
Comparison of mean arterial pressure at different time interval between the two groups (*significant difference) (B = Baseline, ID = Induction, BLOCK = At the time of block, SX = Start of surgery, 10 = 10 min after start of surgery, 20 = 20 min after start of surgery, 30 = 30 min after start of surgery, 40 = 40 min after start of surgery, 50 = 50 min after start of surgery, 60 = 60 min after start of surgery, EX = Extubation)
See this image and copyright information in PMC

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