Achilles heel of Ebola viral entry

Comment

Alexandra Flemming. Nat Rev Drug Discov. 2011.

. 2011 Sep 30;10(10):731.

doi: 10.1038/nrd3568.

No abstract available

Comment on

Small molecule inhibitors reveal Niemann-Pick C1 is essential for Ebola virus infection.
Côté M, Misasi J, Ren T, Bruchez A, Lee K, Filone CM, Hensley L, Li Q, Ory D, Chandran K, Cunningham J. Côté M, et al. Nature. 2011 Aug 24;477(7364):344-8. doi: 10.1038/nature10380. Nature. 2011. PMID: 21866101 Free PMC article.
Ebola virus entry requires the cholesterol transporter Niemann-Pick C1.
Carette JE, Raaben M, Wong AC, Herbert AS, Obernosterer G, Mulherkar N, Kuehne AI, Kranzusch PJ, Griffin AM, Ruthel G, Dal Cin P, Dye JM, Whelan SP, Chandran K, Brummelkamp TR. Carette JE, et al. Nature. 2011 Aug 24;477(7364):340-3. doi: 10.1038/nature10348. Nature. 2011. PMID: 21866103 Free PMC article.