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Editorial
. 2011 Oct;80(8):798-801.
doi: 10.1038/ki.2011.191.

Immunosuppressive treatment of focal segmental glomerulosclerosis: lessons from a randomized controlled trial

Jeroen K J Deegens, Jack F M Wetzels
Free article
Editorial

Immunosuppressive treatment of focal segmental glomerulosclerosis: lessons from a randomized controlled trial

Jeroen K J Deegens et al. Kidney Int. 2011 Oct.
Free article

Abstract

Patients with steroid-resistant focal segmental glomerulosclerosis (FSGS) may benefit from treatment with calcineurin inhibitors. A National Institutes of Health-funded FSGS multicenter study has suggested that a combination of mycophenolate mofetil and oral dexamethasone pulses was equivalent to cyclosporine. However, since the study was underpowered, one cannot draw firm conclusions from this study. The FSGS trial underscores that FSGS is not one disease and that better predictors of outcome and response to therapy are needed.

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Comment on

  • Clinical trial of focal segmental glomerulosclerosis in children and young adults.
    Gipson DS, Trachtman H, Kaskel FJ, Greene TH, Radeva MK, Gassman JJ, Moxey-Mims MM, Hogg RJ, Watkins SL, Fine RN, Hogan SL, Middleton JP, Vehaskari VM, Flynn PA, Powell LM, Vento SM, McMahan JL, Siegel N, D'Agati VD, Friedman AL. Gipson DS, et al. Kidney Int. 2011 Oct;80(8):868-78. doi: 10.1038/ki.2011.195. Epub 2011 Jul 6. Kidney Int. 2011. PMID: 21734640 Free PMC article. Clinical Trial.

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