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. 2012 Apr;27(4):451-7.
doi: 10.1177/0883073811419317. Epub 2011 Sep 29.

Phenobarbital and temperature profile during hypothermia for hypoxic-ischemic encephalopathy

Guilherme Sant'Anna  1 , Abbot R Laptook, Seetha Shankaran, Rebecca Bara, Scott A McDonald, Rosemary D Higgins, Jon E Tyson, Richard A Ehrenkranz, Abhik Das, Ronald N Goldberg, Michele C Walsh; Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network
Collaborators, Affiliations

Phenobarbital and temperature profile during hypothermia for hypoxic-ischemic encephalopathy

Guilherme Sant'Anna et al. J Child Neurol. 2012 Apr.

Abstract

Data from the whole-body hypothermia trial was analyzed to examine the effects of phenobarbital administration prior to cooling (+PB) on the esophageal temperature (T (e)) profile, during the induction phase of hypothermia. A total of 98 infants were analyzed. At enrollment, +PB infants had a higher rate of severe hypoxic-ischemic encephalopathy and clinical seizures and lower T (e) and cord pH than infants that have not received phenobarbital (-PB). There was a significant effect of phenobarbital itself and an interaction between phenobarbital and time in the T (e) profile. Mean T (e) in the +PB group was lower than in the -PB group, and the differences decreased over time. In +PB infants, the time to surpass target T (e) of 33.5°C and to reach the minimum T (e) during overshoot were shorter. In conclusion, the administration of phenobarbital before cooling was associated with changes that may reflect a reduced thermogenic response associated with barbiturates.

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Conflict of interest statement

Conflict of Interest

Authors disclose no commercial, financial, or other associations that could pose a conflict of interest in connection with the submitted article.

Figures

Figure 1
Figure 1
Esophageal temperature profile in +PB and −PB infants during the induction phase of hypothermia.
See this image and copyright information in PMC

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