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Review
. 2011 Nov;53(9):915-26.
doi: 10.1093/cid/cir508. Epub 2011 Sep 29.

Tuberculosis of the central nervous system in immunocompromised patients: HIV infection and solid organ transplant recipients

Christina A Nelson  1 , Joseph R Zunt
Affiliations
Review

Tuberculosis of the central nervous system in immunocompromised patients: HIV infection and solid organ transplant recipients

Christina A Nelson et al. Clin Infect Dis. 2011 Nov.

Abstract

Central nervous system (CNS) tuberculosis (TB) is a devastating infection with high rates of morbidity and mortality worldwide and may manifest as meningitis, tuberculoma, abscess, or other forms of disease. Immunosuppression, due to either human immunodeficiency virus infection or solid organ transplantation, increases susceptibility for acquiring or reactivating TB and complicates the management of underlying immunosuppression and CNS TB infection. This article reviews how immunosuppression alters the clinical presentation, diagnosis, treatment, and outcome of TB infections of the CNS.

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