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Review
. 2011 Sep;38(3):519-35.
doi: 10.1016/j.ogc.2011.05.007.

Perimenopause and cognition

Gail A Greendale  1 , Carol A Derby, Pauline M Maki
Affiliations
Review

Perimenopause and cognition

Gail A Greendale et al. Obstet Gynecol Clin North Am. 2011 Sep.

Abstract

The impact of perimenopause on cognition seems to be characterized by an absence of improved scores rather than a decline. In the SWAN, the perimenopausal decrement in cognitive performance was not accounted for; however, increases in anxiety and depressive symptoms had independent, unfavorable effects on performance. Estradiol has been found to protect against changes resulting from serotonin withdrawal and defend against changes from cholinergic depletion. There is support for the critical timing hypothesis--that estrogen benefits cognitive function when instituted early, but not later. The menopausal transition may affect cognitive function in older age owing to worsened cardiovascular risk factors.

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References

    1. Mitchell E, Woods N. Midlife women’s attributions about perceived memory changes: Observations from the Seattle Midlife Women’s Health Study. J Womens Health Gend Based Med. 2001;10:351–362. - PubMed
    1. Gold EB, Sternfeld B, Kelsey JL, Brown C, Mouton C, Reame N, Salamone L, Stellato R. Relation of demographic and lifestyle factors to symptoms in a multi-racial/ethnic population of women 40–55 years of age. Am J Epidemiol. 2000 Sep;152(5):463–73. - PubMed
    1. McEwen BS. Invited review: estrogens effects on the brain: Multiple sites and molecular mechanisms. J Appl Physiol. 2001;91:2785–2801. - PubMed
    1. McEwen B. Estrogen actions throughout the brain. Recent Prog Horm Res. 2002;57:357–384. - PubMed
    1. Gleason CE, Cholerton B, Carlsson CM, Johnson SC, Asthana S. Neuroprotective effects of female sex steroids in humans: current controversies and future directions. Cell Mol Life Sci. 2005 Feb;62(3):299–312. - PMC - PubMed

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