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. 2011 Sep 30:11:262.
doi: 10.1186/1471-2334-11-262.

Virologic and clinical characteristics of HBV genotypes/subgenotypes in 487 Chinese pediatric patients with CHB

Yan-Wei Zhong  1 , Jin Li, Hong-Bin Song, Zhong-Ping Duan, Yi Dong, Xiao-Yan Xing, Xiao-Dong Li, Mei-Lei Gu, Yu-Kun Han, Shi-Shu Zhu, Hong-Fei Zhang
Affiliations

Virologic and clinical characteristics of HBV genotypes/subgenotypes in 487 Chinese pediatric patients with CHB

Yan-Wei Zhong et al. BMC Infect Dis. .

Abstract

Background: The association of hepatitis B virus (HBV) genotypes/subgenotypes with clinical characteristics is increasingly recognized. However, the virologic and clinical features of HBV genotypes/subgenotypes in pediatric patients remain largely unknown.

Methods: Four hundred and eighty-seven pediatric inpatients with CHB were investigated, including 217 nucleos(t)ide analog-experienced patients. HBV genotypes/subgenotypes and reverse transcriptase (RT) mutations were determined by direct sequencing. The stage of fibrosis and degree of inflammatory activity were evaluated by the Metavir score system.

Results: Among 487 enrolled pediatric patients, HBV genotype C2 and B2 were the most two prevalent (73.7% and 21.1%). Comparing with HBV/B2 infected patients, no significant difference was observed in the incidence rate and mutant patterns of lamivudine- or adefovir-resistant mutations in HBV/C2 infected patients (P > 0.05). Importantly, we found that the degree of hepatic inflammation degree, fibrosis stage and ALT level were significantly higher in HBV/C2-infected HBeAg positive patients than it was in HBV/B2-infected ones.

Conclusions: The pediatric patients with HBV/C2 infection might be more susceptible to develop severe liver pathogenesis.

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Figures

Figure 1
Figure 1
Phylogenetic tree based on 43 representative HBV genetic sequences analyzed with GenBank accession numbers. Standard reference sequences are marked by circles.
See this image and copyright information in PMC

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