Comment
doi: 10.1016/j.cell.2011.09.005.
Translocation mapping exposes the risky lifestyle of B cells
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- PMID: 21962501
- DOI: 10.1016/j.cell.2011.09.005
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Comment
Translocation mapping exposes the risky lifestyle of B cells
Cell.
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Free article
Abstract
Recurrent chromosomal translocations can drive oncogenesis, but how they form has remained elusive. Now, Chiarle et al. (2011) and Klein et al. (2011) characterize the genome-wide spectrum of translocations that form from a single double-stranded break, revealing that specific loci have an intrinsic predisposition for frequent chromosomal rearrangements.
Copyright © 2011 Elsevier Inc. All rights reserved.
Comment on
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Translocation-capture sequencing reveals the extent and nature of chromosomal rearrangements in B lymphocytes.Cell. 2011 Sep 30;147(1):95-106. doi: 10.1016/j.cell.2011.07.048. Cell. 2011. PMID: 21962510 Free PMC article.
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Genome-wide translocation sequencing reveals mechanisms of chromosome breaks and rearrangements in B cells.Cell. 2011 Sep 30;147(1):107-19. doi: 10.1016/j.cell.2011.07.049. Cell. 2011. PMID: 21962511 Free PMC article.
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