Review
doi: 10.1016/j.jaad.2011.08.025.
Epub 2011 Oct 1.
Leflunomide in dermatology
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- PMID: 21962758
- DOI: 10.1016/j.jaad.2011.08.025
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Review
Leflunomide in dermatology
J Am Acad Dermatol.
2012 Apr.
Abstract
Leflunomide is an oral disease-modifying antirheumatic drug administered to patients with rheumatoid and psoriatic arthritis. This drug inhibits dihydroorotate dehydrogenase, an enzyme critical in the production of intracellular pyrimidines, and down-regulates tumor necrosis factor-alfa activity. Leflunomide has demonstrated usefulness in treating cutaneous psoriasis along with other dermatologic and rheumatologic conditions.
Copyright © 2011 American Academy of Dermatology, Inc. Published by Mosby, Inc. All rights reserved.
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