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. 2012 Jan;95(1):42-7.
doi: 10.1016/j.diabres.2011.09.006. Epub 2011 Sep 29.

Serum 25-hydroxyvitamin D concentration and arterial stiffness among type 2 diabetes

Jee-In Lee  1 , Su-Jin Oh, Won-Chul Ha, Hyuk-Sang Kwon, Tae-Seo Sohn, Hyun-Shik Son, Bong-Yun Cha
Affiliations

Serum 25-hydroxyvitamin D concentration and arterial stiffness among type 2 diabetes

Jee-In Lee et al. Diabetes Res Clin Pract. 2012 Jan.

Abstract

Aim: To evaluate the association between serum 25-hydroxyvitamin D [25(OH)D] and arterial stiffness in patients with type 2 diabetes.

Methods: Serum 25(OH)D was measured in a cross-sectional sample of 131 men and 174 women aged 30 years and over in Korea. Arterial stiffness was assessed by pulse wave velocity (PWV) obtained with a VP-2000 pulse wave unit. Fasting plasma glucose, insulin, lipid profile, HbA1c, calcium, phosphorous, and HS-CRP were measured.

Results: The prevalence of vitamin D deficiency was high (85.9%). Those with lower vitamin D levels had increased PWV. Using multivariate regression analysis, low 25(OH)D concentrations independently predicted PWV (p<0.001) in people with type 2 diabetes after adjustment for other risk factors such as age, smoking, hypertension, HS-CRP, diabetes duration, hypertension duration, HbA1c, and BMI.

Conclusions: Vitamin D deficiency is common in type 2 diabetes, and a low 25(OH)D level is significantly associated with increased arterial stiffness in these patients. Vitamin D may influence the development of cardiovascular disease. Clinical intervention studies are needed to clarify whether treatment with vitamin D decreases the risk of cardiovascular disease in patients with type 2 diabetes.

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